NIPT tests (noninvasive prenatal testing test) use a pregnant persons blood to detect congenital abnormalities in the fetuss DNA. I will likely decline invasive testing like amniocentesis. The test is slightly less accurate for detecting trisomy 18 and 13. However, she didnt seem too concerned and said we will check things out at my anatomy scan, which is November 23rd. Cell free DNA screening is not a simple blood test. We had anatomy scan this week and everything seems okay. I have my anatomy scan on Wednesday but Im just so terrified they will give me bad news. The CVS came back perfect - no abnormalities. Strangely enough, I am also on lovenox.I am also old at 39 and have a higher BMI. First test, done at 12 weeks, took 2 weeks for them to get back to me and say was inconclusive, so I had a redraw a week and a half ago at 14 weeks. We just got our results back and have a perfectly healthy eggo. I dont have any advice. There is a 0% chance of survival with this condition so we are looking into terminating in the next few days not my rainbow baby after all.. Also, all of the anatomy scans have come back perfect. Learn more about, Twins & Multiples: Your Tentative Time Table. https://amp.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, the most helpful and trustworthy pregnancy and parenting information. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. We had two inconclusive NIPT tests (from two different testing companies). Would knowing this information help my provider(s) take better care of the baby? This is called the fetal fraction. I realize I may have been taking about something different. Please whitelist our site to get all the best deals and offers from our partners. Noninvasive pregnancy screening tests are a personal choice. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Yes, Harmony is NIPT. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Note that once you confirm, this action cannot be undone. Please specify a reason for deleting this reply from the community. It can't do genetic risks though. This test can be done beginning at 10 weeks of pregnancy. Well, my redraw came back inconclusive, but the NT ultrasounds were reassuring (I am carrying twins). Same thing happened to me. Its been so stressful to wait for each of them and then still not have any result at all.. NIPT tests dont diagnose conditions. Its soo nerve breaking!! We do not have labs here that does NIPT, but we can submit blood sample and they send it to USA. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Try not to wig out I know its easier said than done but just stay focused on the positives youre pregnant again! I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. I have also read that certain medications can interfere so that is totally possible that its what happened in your case. It has to be at least above 4 percent to give a conclusive result. I do think that its such a fighter since it lasted so long fingers crossed its healthy. It is super frustrating, and I think honestly more frustrating that docs continue to recommend these tests when it seems like everyone I know with a high BMI had this issue. NIPT tests are safe, and theres no risk to the fetus. 1997-2023 BabyCenter, LLC, a Ziff Davis company. So after 9 weeks of genetic testing and no results we were finally able to get results and everything has turned out ok and we are having a baby boy! If your baby still has a heartbeat now, maybe that means that the baby doesnt have that. He sent me to do echocardiography which also was good and show no signs for pathologies. I just did a retest last week because mine came back inconclusive!! Your healthcare provider will provide information about prenatal genetic testing and help you make an informed choice about your options. Learn more about, Twins & Multiples: Your Tentative Time Table. If youre having a difficult time or wish to discuss the screenings in more detail, a genetic counselor can help you understand the prenatal testing options and what may be a good fit for you. Praying for all babies too come back clear and healthy!! Mine came back inconclusive also. rU%`_@j)4KYm9"PR Xb@{i#n->`#4sI2n# ! We will not be doing anymore testing for baby boy #3. I took the testing at 16 was I. 2005-2023Everyday Health, Inc., a Ziff Davis company. Healthcare providers may recommend it if you: The American College of Obstetricians and Gynecologists (ACOG) used only to recommend NIPT for pregnant people considered high risk. As far as 16 weeks ultrasound, sex was pretty obvious on mine . I had inconclusive NIPT results. thank you so much. Has anyone experienced this? I think if the scan/bloods come back clear then I wont do a third one (just more worry/waiting) but if there is anything not good I will have to decide to either do a third NIPT or more invasive procedures (which I would really want to avoid!). You apparently have too much blood for an accurate reading. (https://medlineplus.gov/genetics/understanding/testing/nipt/). Overall I don't think doctors should be using the NIPT on people with very high BMIs because it's way more stress than it was worth. Hey lovely - where are you based? I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. E@Gpc 8Op!ISHiT7{;-N/OM7Mq+YV1d)|\i-V;`]tyTAHqAFWR The most common sex chromosome conditions are Turner syndrome, Klinefelter syndrome, Triple X syndrome and XYY syndrome. NIPT is a screening test and, therefore, isnt perfect. All rights reserved. 20062023 BabyCenter, LLC, a Ziff Davis company. Its important to remember that a screening test estimates the likelihood of the fetus having a particular condition. I did IVF and my embryo was a normal embryo through pgt so that gives me hope. I met with a genetics counselor and decided to do a 3rd round of genetic testing through Myriad! Reasons behind an inconclusive prenatal paternity test. Has this happened to anyone else? You wont get the gender but youll find out if baby is healthy x x, Im am from Latvia (Europe). I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. She said it worked for almost all her patients. Are you tall? Understanding what the NIPT test results mean. The first test they ran apparently i did not have enough fetal DNA i took another one and the same results, should I be concerned? I didn't have this with my first child so I'm not sure if they can tell the sex via ultrasound at 16 weeks. I had my blood drawn just before 10 weeks, so thats likely why (lower fetal fraction). Are you doing the NT scan & bloods as well? If you'd continue the pregnancy regardless of any defects, then I think you can definitely skip the amnio. I had the first done at 13w and second done at 16w. We strive to provide you with a high quality community experience. Which means your placenta isnt functioning properly? Originally my doctor said we would take another blood sample once I was further along around 16 weeks and try again if it didn't work initially. My anatomy scan is the 16th so praying everything will come back normal. Yes with Natera Panaroma, I had inconclusives twice & declined the third redraw. Inconclusive on gender results? I feel like Im holding myself together for now but that I can brake at any point so very wary of how I will deal with a second loss in a row :(. This happened to me as well. And like pp said.I hope your anatomy scan is smooth sailing and you can see that the baby is fine and healthy. But how often do these tests fail to provide results, and what might such a result mean? 69 0 obj <> endobj For the most . I had the first done at 13w and second done at 16w. Just got my results back yesterday with a BMI of 47. 87 0 obj <>/Filter/FlateDecode/ID[<4B4A02C4438C2E458275BA0029DF7841>]/Index[69 39]/Info 68 0 R/Length 93/Prev 142855/Root 70 0 R/Size 108/Type/XRef/W[1 2 1]>>stream She didnt suggest further testing. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. In this case, you can repeat the NIPT test and hope for a result the second time. Overwhelmed and frustrated by weight gain. Your healthcare provider will receive your test results first, then share the results with you. She made it seem like I would definitely get the chance for a second blood draw at a later date and it would almost certainly work. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Your post will be hidden and deleted by moderators. Hope you are getting all the support you need and sending good healthy babe energy your way! Are you taking aspirin? Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. The #1 app for tracking pregnancy and baby growth. Would I do something different knowing the fetus has a genetic condition or an increased risk for a genetic condition? I just did the basic scan and blood work covered by Ohip. We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! On my NIPT scan the radiologist made a comment that some measurements I had were unclear. Yes, NIPT can be done anytime after 10 weeks of pregnancy. Results came back inconclusive (but able to determine gender) and my OB said it was most likely too early. NIPT (Harmony test) inconclusive twice. I have never heard of two inconclusive results! Has anyone had this? Overall, NIPT tests produce fewer false positives than other prenatal screenings like the quad screen. Most health insurances cover most (if not all) of the cost. I called the doctors office today to check on my second Panorama test and they informed the test came back again inconclusive due to low fetal fraction. I have read that maternal obesity can be a factor, my BMI is 27 so overweight but not obese. Anyone else go through this and get good results? The reason that your doctor is suggesting an ammio is because studies have shown there is a positive correlation between a low percentage of fetal DNA (i.e. What was the outcome? NIPT cant screen for all chromosomal or genetic conditions. Really sending you love and support. I'm so sorry your going through this stressful situation , Got the quad back! yeah I declined the redraw also and decided to wait. I agree with PP. Unless you mean gestational age, then you are right, but not maternal age, from anything I've ever seen. (https://www.smfm.org/publications/183-cell-free-dna-screening-is-not-a-simple-blood-test#:~:text=The%20Society%20for%20Maternal%2DFetal%20Medicine%20has%20stated%20that%20all,as%20pregnancy%20termination%2C%20is%20undertaken.). Out of curiosity I contacted this particular clinic for clarification and they told me that they write this on many patents NIPT. My doctor didnt seem too concerned, as apparently they come back inconclusive all the time. This is a red flag for chromosomal Natera NIPT 2nd Try Results. I had to do the NIPT test twice. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Had to redraw today and start the waiting process all over. I had an inconclusive harmony test at 10 weeks exactly, I wasn't too worried as it was really early, I was on blood thinners, and a higher bmi of 30, all of which can lead to an inconclusive result. So relieved! During this test, your provider takes a sample of your blood to look for abnormalities in the fetuss DNA. K/!0p8v?vbs#.TOc %>.n>pJKps,m0T7-r*Y:p HB&~=^D_|+wIG0s(i]A[p{{9lfvrXiOsd$f{U&K>VY?-3K?gHG|;%nG\O#@'u}mtlDFCgoo>oH![mM*rYauM('@6Gsyc1ER91`o8vk@02>n]FFPl?#=p""?qoir7.[ RU'^G'ulAI$EW0]_.6L8Le. . NIPT is a screening test, which means that it wont give a yes or no answer about whether or not a fetus has a condition. Most labs give separate results for each condition theyre screening for. Maybe call the clinic directly for feedback on how that particular radiologist writes reports. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. My BMI is a bit high and I've read that can be a reason. I ended up asking for a quad screen (it wasnt covered by my insurance but was like $30) to assess risk for trisomy 21, 18 and spina bifida. The following questions might be helpful to you as you make your decision: NIPT testing costs vary. Another inconclusive result. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Mine came back inconcl, I was 12 weeks and then took again at 14 1D, I have also had 2 inconclusive results and we are not trying again. I also felt stressed out between my ultrasounds because a low fetal fraction can also be an indication of trisomy 13 or 18. So I just found out that my NIPT came back with low fetal fraction for the second time. I have read this is an issue for plus size women and the other factor is age. Trying not to worry.but I am. However, they got all the ones they needed for the NIPT which were good. Your test result shows that your pregnancy is at low risk for these three conditions. I wanted to wait a few weeks so the baby would be bigger and I would have a better chance of getting a result. NIPT is about 99% accurate in detecting Down syndrome. Now it is considered high risk and listed a 1/17 chance of a chromosome issue. We are going to do the quad screen and a detailed ultrasound next week. Please specify a reason for deleting this reply from the community. Im going through the exact same. This happened to me as well. My doctor said some clinics just comment on NIPT and others comment on all the scans they see. Its important to talk to your healthcare provider about what your NIPT is screening for. Is this an ivf pregnancy? Results from first trimester screening came back low for t21, t13, t18 My doctor just did not liked that NT measured 2.6mm and that was the reason she sent me to do NIPT. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, (https://www.acog.org/womens-health/faqs/prenatal-genetic-screening-tests), (https://www.acog.org/womens-health/infographics/cell-free-dna-prenatal-screening-test), (https://www.cdc.gov/ncbddd/birthdefects/diagnosis.html). So I'm not sure how it was for you. Can I ask how your Quad screening went?